| Date | Location | Result | |
| 03/19/22 | Daytona Beach, FL (Ocean Center) | Drake 87, Purdue Fort Wayne 65 | Box score |
| 03/07/22 | Indianapolis, IN | Northern Ky. 57, Purdue Fort Wayne 43 | Box score |
| 03/03/22 | Fort Wayne, IN | Purdue Fort Wayne 78, UIC 72 | Box score |
| 02/26/22 | Detroit, MI | Purdue Fort Wayne 81, Detroit Mercy 78 | Box score |
| 02/24/22 | Rochester, MI | Purdue Fort Wayne 81, Oakland 70 | Box score |
| 02/20/22 | Milwaukee, WI | Purdue Fort Wayne 81, Milwaukee 71 | Box score |
| 02/18/22 | Green Bay, WI | Purdue Fort Wayne 74, Green Bay 55 | Box score |
| 02/14/22 | Fort Wayne, IN | Purdue Fort Wayne 102, Cleveland St. 98 (3OT) | Box score |
| 02/12/22 | Fort Wayne, IN | Purdue Fort Wayne 73, UIC 66 | Box score |
| 02/10/22 | Fort Wayne, IN | Purdue Fort Wayne 72, IUPUI 57 | Box score |
| 02/06/22 | Fort Wayne, IN | Purdue Fort Wayne 71, Green Bay 55 | Box score |
| 02/04/22 | Fort Wayne, IN | Purdue Fort Wayne 70, Milwaukee 60 | Box score |
| 01/30/22 | Fairborn, OH | Wright St. 75, Purdue Fort Wayne 63 | Box score |
| 01/28/22 | Highland Heights, KY | Northern Ky. 59, Purdue Fort Wayne 49 | Box score |
| 01/23/22 | Fort Wayne, IN | Purdue Fort Wayne 82, Youngstown St. 71 | Box score |
| 01/21/22 | Fort Wayne, IN | Purdue Fort Wayne 86, Robert Morris 62 | Box score |
| 01/17/22 | Fort Wayne, IN | Purdue Fort Wayne 102, Mich.-Dearborn 59 | Box score |
| 01/15/22 | Fort Wayne, IN | Oakland 76, Purdue Fort Wayne 68 | Box score |
| 01/13/22 | Fort Wayne, IN | Purdue Fort Wayne 62, Detroit Mercy 60 | Box score |
| 01/09/22 | Moon Township, PA | Purdue Fort Wayne 76, Robert Morris 70 | Box score |
| 01/07/22 | Youngstown, OH | Purdue Fort Wayne 71, Youngstown St. 61 | Box score |
| 01/05/22 | Cleveland, OH | Cleveland St. 65, Purdue Fort Wayne 58 | Box score |
| 12/30/21 | Cleveland, OH | Cleveland St. 90, Purdue Fort Wayne 81 | Box score |
| 12/11/21 | Fort Wayne, IN | Purdue Fort Wayne 78, Southeast Mo. St. 65 | Box score |
| 12/08/21 | Edwardsville, IL | SIUE 80, Purdue Fort Wayne 59 | Box score |
| 12/04/21 | Fort Wayne, IN | Purdue Fort Wayne 71, Northern Ky. 57 | Box score |
| 12/02/21 | Fort Wayne, IN | Wright St. 86, Purdue Fort Wayne 73 | Box score |
| 11/28/21 | Fort Myers, FL | FGCU 85, Purdue Fort Wayne 78 | Box score |
| 11/27/21 | Fort Myers, FL | Western Mich. 93, Purdue Fort Wayne 85 (OT) | Box score |
| 11/26/21 | Fort Myers, FL | Purdue Fort Wayne 74, Southeastern La. 66 | Box score |
| 11/19/21 | Minneapolis, MN | Minnesota 78, Purdue Fort Wayne 49 | Box score |
| 11/16/21 | Fort Wayne, IN | Purdue Fort Wayne 65, Austin Peay 60 | Box score |
| 11/09/21 | Fort Wayne, IN | Purdue Fort Wayne 103, Earlham 54 | Box score |