| Date | Location | Result | |
| 11/12/21 | Fort Wayne, IN | Purdue Fort Wayne 3, IUPUI 1 (25-16,26-24,16-25,25-16) | Box score |
| 11/06/21 | Fort Wayne, IN | Northern Ky. 3, Purdue Fort Wayne 2 (26-24,16-25,21-25,25-17,15-9) | Box score |
| 11/05/21 | Fort Wayne, IN | Wright St. 3, Purdue Fort Wayne 0 (29-27,25-18,25-19) | Box score |
| 10/30/21 | Fort Wayne, IN | Youngstown St. 3, Purdue Fort Wayne 1 (21-25,25-23,25-23,27-25) | Box score |
| 10/29/21 | Fort Wayne, IN | Purdue Fort Wayne 3, Robert Morris 1 (25-20,25-10,20-25,25-11) | Box score |
| 10/24/21 | Chicago, IL | UIC 3, Purdue Fort Wayne 2 (25-22,23-25,23-25,25-15,15-4) | Box score |
| 10/22/21 | Green Bay, WI | Purdue Fort Wayne 3, Green Bay 1 (25-18,25-20,26-28,25-15) | Box score |
| 10/21/21 | Milwaukee, WI | Milwaukee 3, Purdue Fort Wayne 0 (25-18,25-13,25-13) | Box score |
| 10/15/21 | Indianapolis, IN | IUPUI 3, Purdue Fort Wayne 1 (25-22,25-22,20-25,27-25) | Box score |
| 10/12/21 | Fort Wayne, IN | Purdue Fort Wayne 3, Cleveland St. 1 (25-22,21-25,26-24,25-18) | Box score |
| 10/09/21 | Fairborn, OH | Wright St. 3, Purdue Fort Wayne 0 (25-16,25-21,25-21) | Box score |
| 10/08/21 | Highland Heights, KY | Northern Ky. 3, Purdue Fort Wayne 0 (25-20,25-20,25-17) | Box score |
| 10/02/21 | Youngstown, OH | Purdue Fort Wayne 3, Youngstown St. 0 (25-18,25-15,25-20) | Box score |
| 10/01/21 | Moon Township, PA | Purdue Fort Wayne 3, Robert Morris 1 (23-25,26-24,25-21,25-20) | Box score |
| 09/28/21 | Rochester, MI | Oakland 3, Purdue Fort Wayne 2 (27-25,22-25,16-25,25-13,15-13) | Box score |
| 09/26/21 | Fort Wayne, IN | UIC 3, Purdue Fort Wayne 2 (19-25,25-22,25-23,18-25,15-12) | Box score |
| 09/24/21 | Fort Wayne, IN | Milwaukee 3, Purdue Fort Wayne 1 (25-10,16-25,25-12,25-17) | Box score |
| 09/23/21 | Fort Wayne, IN | Green Bay 3, Purdue Fort Wayne 2 (24-26,25-17,25-14,19-25,15-10) | Box score |
| 09/18/21 | West Lafayette, IN | Jacksonville St. 3, Purdue Fort Wayne 1 (25-19,21-25,25-15,25-16) | Box score |
| 09/17/21 | West Lafayette, IN | Purdue 3, Purdue Fort Wayne 0 (25-19,25-6,25-12) | Box score |
| 09/17/21 | West Lafayette, IN | Tennessee 3, Purdue Fort Wayne 0 (25-22,25-20,25-19) | Box score |
| 09/14/21 | Fort Wayne, IN | Toledo 3, Purdue Fort Wayne 0 (25-21,25-19,25-23) | Box score |
| 09/11/21 | Lynchburg, VA | Old Dominion 3, Purdue Fort Wayne 1 (14-25,25-20,25-23,25-17) | Box score |
| 09/11/21 | Lynchburg, VA | Purdue Fort Wayne 3, Liberty 2 (25-18,24-26,10-25,25-20,15-10) | Box score |
| 09/10/21 | Lynchburg, VA | Navy 3, Purdue Fort Wayne 0 (25-19,25-16,25-18) | Box score |
| 09/04/21 | Kalamazoo, MI | Purdue Fort Wayne 3, Western Mich. 1 (25-15,25-21,20-25,28-26) | Box score |
| 09/04/21 | Kalamazoo, MI | Indiana 3, Purdue Fort Wayne 0 (25-16,25-21,25-17) | Box score |
| 09/03/21 | Kalamazoo, MI | Southeast Mo. St. 3, Purdue Fort Wayne 0 (25-14,25-22,25-18) | Box score |
| 08/28/21 | Fort Wayne, IN | Kent St. 3, Purdue Fort Wayne 2 (22-25,25-22,25-21,20-25,18-16) | Box score |
| 08/28/21 | Fort Wayne, IN | Evansville 3, Purdue Fort Wayne 0 (25-23,25-23,27-25) | Box score |
| 08/27/21 | Fort Wayne, IN | SIUE 3, Purdue Fort Wayne 2 (20-25,25-19,14-25,25-19,15-11) | Box score |