| Date | Location | Result | |
| May 25, 2022 | Dayton, Ohio | Youngstown State 6, Purdue Fort Wayne 0 | Box score |
| May 21, 2022 | Akron, Ohio | Akron 11, Purdue Fort Wayne 0 | Box score |
| May 20, 2022 | Akron, Ohio | Akron 7, Purdue Fort Wayne 6 | Box score |
| May 20, 2022 | Akron, Ohio | Purdue Fort Wayne 6, Akron 5 | Box score |
| May 17, 2022 | Fort Wayne, Ind. | Purdue Fort Wayne 4, Butler 2 | Box score |
| May 14, 2022 | Dayton, Ohio | Wright State 17, Purdue Fort Wayne 3 | Box score |
| May 14, 2022 | Dayton, Ohio | Purdue Fort Wayne 5, Wright State 4 | Box score |
| May 13, 2022 | Fort Wayne, Ind. | Purdue Fort Wayne 14, Milwaukee 4 | Box score |
| May 13, 2022 | Fort Wayne, Ind. | Purdue Fort Wayne 2, Milwaukee 1 | Box score |
| May 10, 2022 | Dayton, Ohio | Dayton 8, Purdue Fort Wayne 5 | Box score |
| May 08, 2022 | Chicago, Ill. | UIC 11, Purdue Fort Wayne 6 | Box score |
| May 08, 2022 | Chicago, Ill. | Purdue Fort Wayne 3, UIC 2 | Box score |
| May 01, 2022 | Fort Wayne, Ind. | UIC 21, Purdue Fort Wayne 5 | Box score |
| Apr 30, 2022 | Fort Wayne, Ind. | UIC 4, Purdue Fort Wayne 2 | Box score |
| Apr 29, 2022 | Fort Wayne, Ind. | UIC 7, Purdue Fort Wayne 3 | Box score |
| Apr 27, 2022 | East Lansing, Mich. | Michigan State 7, Purdue Fort Wayne 4 | Box score |
| Apr 24, 2022 | Fort Wayne, Ind. | Oakland 9, Purdue Fort Wayne 7 | Box score |
| Apr 24, 2022 | Fort Wayne, Ind. | Oakland 8, Purdue Fort Wayne 6 | Box score |
| Apr 22, 2022 | Fort Wayne, Ind. | Purdue Fort Wayne 4, Northern Kentucky 3 | Box score |
| Apr 22, 2022 | Fort Wayne, Ind. | Purdue Fort Wayne 4, Northern Kentucky 2 | Box score |
| Apr 20, 2022 | South Bend, Ind. | Notre Dame 12, Purdue Fort Wayne 2 | Box score |
| Apr 16, 2022 | Highland Heights, Ky | Purdue Fort Wayne 10, Northern Kentucky 5 | Box score |
| Apr 15, 2022 | Highland Heights, Ky | Northern Kentucky 5, Purdue Fort Wayne 4 | Box score |
| Apr 14, 2022 | Highland Heights, Ky | Purdue Fort Wayne 9, Northern Kentucky 5 | Box score |
| Apr 10, 2022 | Franklin, Wis. | Purdue Fort Wayne 7, Milwaukee 6 | Box score |
| Apr 09, 2022 | Franklin, Wis. | Purdue Fort Wayne 7, Milwaukee 0 | Box score |
| Apr 09, 2022 | Franklin, Wis. | Purdue Fort Wayne 5, Milwaukee 4 | Box score |
| Apr 06, 2022 | Ann Arbor, Mich. | Purdue Fort Wayne 6, Michigan 3 | Box score |
| Apr 03, 2022 | Fort Wayne, Ind. | Wright State 12, Purdue Fort Wayne 3 | Box score |
| Apr 02, 2022 | Fort Wayne, Ind. | Wright State 17, Purdue Fort Wayne 11 | Box score |
| Apr 01, 2022 | Fort Wayne, Ind. | Wright State 5, Purdue Fort Wayne 3 | Box score |
| Mar 29, 2022 | Valparaiso, Ind. | Purdue Fort Wayne 11, Valparaiso 3 | Box score |
| Mar 26, 2022 | West Bloomfield, MI | Oakland 10, Purdue Fort Wayne 9 | Box score |
| Mar 25, 2022 | Rochester, Mich. | Oakland 10, Purdue Fort Wayne 2 | Box score |
| Mar 25, 2022 | Rochester, Mich. | Purdue Fort Wayne 10, Oakland 2 | Box score |
| Mar 20, 2022 | Defiance, Ohio | Youngstown State 12, Purdue Fort Wayne 6 | Box score |
| Mar 20, 2022 | Defiance, Ohio | Purdue Fort Wayne 8, Youngstown State 7 | Box score |
| Mar 18, 2022 | Fort Wayne, Ind. | Youngstown State 4, Purdue Fort Wayne 0 | Box score |
| Mar 16, 2022 | Fort Wayne, Ind. | Dayton 8, Purdue Fort Wayne 4 | Box score |
| Mar 13, 2022 | St. Louis, Mo. | Saint Louis 5, Purdue Fort Wayne 2 | Box score |
| Mar 13, 2022 | St. Louis, Mo. | Purdue Fort Wayne 4, Saint Louis 1 | Box score |
| Mar 10, 2022 | St. Louis, Mo. | Saint Louis 5, Purdue Fort Wayne 2 | Box score |
| Mar 09, 2022 | Bloomington, Ind. | Indiana 12, Purdue Fort Wayne 2 | Box score |
| Mar 06, 2022 | Cookeville, Tenn. | Tennessee Tech 15, Purdue Fort Wayne 7 | Box score |
| Mar 05, 2022 | Cookeville, Tenn. | Tennessee Tech 7, Purdue Fort Wayne 1 | Box score |
| Mar 04, 2022 | Cookeville, Tenn. | Tennessee Tech 13, Purdue Fort Wayne 4 | Box score |
| Feb 27, 2022 | Riverside, Calif. | California Baptist 11, Purdue Fort Wayne 1 | Box score |
| Feb 26, 2022 | Riverside, Calif. | California Baptist 5, Purdue Fort Wayne 3 | Box score |
| Feb 26, 2022 | Riverside, Calif. | California Baptist 23, Purdue Fort Wayne 5 | Box score |
| Feb 25, 2022 | Riverside, Calif. | California Baptist 4, Purdue Fort Wayne 2 | Box score |
| Feb 20, 2022 | Atlanta, Ga. | Georgia State 8, Purdue Fort Wayne 7 | Box score |
| Feb 19, 2022 | Atlanta, Ga. | Georgia State 6, Purdue Fort Wayne 5 | Box score |
| Feb 19, 2022 | Atlanta, Ga. | Georgia State 12, Purdue Fort Wayne 2 | Box score |
| Feb 18, 2022 | Atlanta, Ga. | Georgia State 13, Purdue Fort Wayne 2 | Box score |