| Date | Location | Result | |
| 03/01/22 | Moon Township, PA | Robert Morris 70, Purdue Fort Wayne 56 | Box score |
| 02/26/22 | Fort Wayne, IN | Milwaukee 53, Purdue Fort Wayne 51 | Box score |
| 02/24/22 | Fort Wayne, IN | Green Bay 73, Purdue Fort Wayne 57 | Box score |
| 02/19/22 | Rochester, MI | Oakland 58, Purdue Fort Wayne 54 | Box score |
| 02/17/22 | Detroit, MI | Purdue Fort Wayne 77, Detroit Mercy 62 | Box score |
| 02/13/22 | Fort Wayne, IN | Youngstown St. 69, Purdue Fort Wayne 55 | Box score |
| 02/11/22 | Fort Wayne, IN | Robert Morris 60, Purdue Fort Wayne 48 | Box score |
| 02/07/22 | Fort Wayne, IN | Purdue Fort Wayne 72, Taylor (IN) 61 | Box score |
| 02/05/22 | Fort Wayne, IN | Purdue Fort Wayne 83, Wright St. 58 | Box score |
| 02/03/22 | Fort Wayne, IN | Northern Ky. 67, Purdue Fort Wayne 43 | Box score |
| 01/29/22 | Chicago, IL | Purdue Fort Wayne 88, UIC 61 | Box score |
| 01/27/22 | Indianapolis, IN | IUPUI 74, Purdue Fort Wayne 55 | Box score |
| 01/22/22 | Fort Wayne, IN | Cleveland St. 80, Purdue Fort Wayne 58 | Box score |
| 01/20/22 | Cleveland, OH | Cleveland St. 85, Purdue Fort Wayne 59 | Box score |
| 01/14/22 | Milwaukee, WI | Milwaukee 68, Purdue Fort Wayne 56 | Box score |
| 01/08/22 | Fort Wayne, IN | Purdue Fort Wayne 62, Detroit Mercy 57 | Box score |
| 01/06/22 | Fort Wayne, IN | Oakland 63, Purdue Fort Wayne 60 | Box score |
| 01/01/22 | Moon Township, PA | Robert Morris 52, Purdue Fort Wayne 48 | Box score |
| 12/30/21 | Youngstown, OH | Youngstown St. 64, Purdue Fort Wayne 41 | Box score |
| 12/20/21 | Fort Wayne, IN | Indiana St. 55, Purdue Fort Wayne 53 | Box score |
| 12/12/21 | Notre Dame, IN | Notre Dame 78, Purdue Fort Wayne 41 | Box score |
| 12/09/21 | Cape Girardeau, MO | Southeast Missouri 68, Purdue Fort Wayne 51 | Box score |
| 12/05/21 | Highland Heights, KY | Northern Ky. 69, Purdue Fort Wayne 60 | Box score |
| 12/02/21 | Muncie, IN | Ball St. 86, Purdue Fort Wayne 58 | Box score |
| 11/28/21 | Edwardsville, IL | SIUE 68, Purdue Fort Wayne 56 | Box score |
| 11/24/21 | Fort Wayne, IN | Evansville 84, Purdue Fort Wayne 71 | Box score |
| 11/18/21 | Fort Wayne, IN | Purdue Fort Wayne 69, UIC 63 | Box score |
| 11/09/21 | Fort Wayne, IN | Purdue Fort Wayne 102, Manchester 35 | Box score |