| Date | Location | Result | |
| 10/31/21 | Newport, UNITED STAT | Northern Ky. 1, Purdue Fort Wayne 0 (OT) | Box score |
| 10/27/21 | Fort Wayne, UNITED S | Cleveland St. 1, Purdue Fort Wayne 0 | Box score |
| 10/23/21 | Detroit, UNITED STAT | Purdue Fort Wayne 1, Detroit Mercy 1 (2OT) | Box score |
| 10/17/21 | Green Bay | Purdue Fort Wayne 1, Green Bay 1 (2OT) | Box score |
| 10/14/21 | Fort Wayne, UNITED S | Purdue Fort Wayne 1, Youngstown St. 0 | Box score |
| 10/10/21 | Fort Wayne, UNITED S | Purdue Fort Wayne 2, Wright St. 1 | Box score |
| 10/07/21 | Newport, UNITED STAT | Northern Ky. 6, Purdue Fort Wayne 2 | Box score |
| 10/02/21 | Milwaukee, United St | Milwaukee 2, Purdue Fort Wayne 1 (2OT) | Box score |
| 09/26/21 | Fort Wayne, UNITED S | Oakland 1, Purdue Fort Wayne 0 | Box score |
| 09/23/21 | Moon, UNITED STATES | Purdue Fort Wayne 3, Robert Morris 2 (OT) | Box score |
| 09/19/21 | Indianapolis, Ind., | IUPUI 1, Purdue Fort Wayne 0 | Box score |
| 09/16/21 | Fort Wayne, UNITED S | Purdue Fort Wayne 2, UIC 0 | Box score |
| 09/10/21 | Bridgeview, UNITED S | Purdue Fort Wayne 2, Chicago St. 2 (2OT) | Box score |
| 09/05/21 | Muncie, UNITED STATE | Ball St. 3, Purdue Fort Wayne 1 | Box score |
| 09/02/21 | Iowa City, UNITED ST | Iowa 5, Purdue Fort Wayne 0 | Box score |
| 08/29/21 | Louisville, UNITED S | Purdue Fort Wayne 1, Bellarmine 1 (2OT) | Box score |
| 08/27/21 | Fort Wayne, UNITED S | Eastern Ill. 0, Purdue Fort Wayne 0 (2OT) | Box score |
| 08/22/21 | Fort Wayne, UNITED S | Purdue Fort Wayne 3, Morehead St. 1 | Box score |
| 08/19/21 | Fort Wayne, UNITED S | Toledo 0, Purdue Fort Wayne 0 (2OT) | Box score |